The Glysious technology can be used for virtually any substance that is desired delivered to the skin or to the wound. Hydrophilic substances, such as hydroquinone, vitamins B and C, and niacinamide, can be dissolved readily in glycerol. Hydrophobic substances, such as vitamins A, D and E, as well as CBD, THC and oils in general, can be emulsified in the glycerol or solubilized by means of surfactants and thereby be compatible with the Glysious system. Amphiphilic substances may also be used directly or be formulated with formulation aids.