top of page

Versatile technology platform

Technology platform is based on unique stability of glycerol and silicone mixtures and controlled release of active substances from glycerol domains 

Technology originates from multi-year project at the Danish Polymer Centre of the Technical University of Denmark, DTU

 

Distinctive features of Glysious technology

High breathability

Silicone is 10 times more permeable than other adhesives, such as acrylics

Glycerol-silicone patches/films are more than twice as permeable than silicone adhesives

Zero-order (constant) release

Silicone is 10 times more permeable than other adhesives, such as acrylics

Release profile is tunable 

Water handling 

Liquid (serum, sweat and water) absorption increase with glycerol content

Patches do not lose mechanical integrity upon liquid uptake

Liquid uptake has no impact on mechanical features of patch

Predictable release

​Active substance release rate can be tuned via
 

  • glycerol content

  • active substance concentration

  • thickness of adhesive 

Multiple actives loading

Storage stability – even for reactive substances

Independent release profiles 

Stabilisation of actives

Measured half-lives of vitamin C: 

  • in water 70 days 

  • in glycerol: 129 days 

  • in Glysious product/packed: 700 days
     

Active substance release mechanism

Glycerol domains embedded within a silicone matrix act as reservoirs for active substances

Upon contact with wounds, skin or any aqueous media, active substance is released from adhesive due to diffusion​

 

Examples of technology key features

Water absorption and permeability increase with glycerol content 
 
 phr: weight parts of glycerol per hundred weight parts of silicone
Glycerol-silicone adhesives with excellent fluid handling and mechanical properties for ad

Examples of technology key features

Release rate is tunable by glycerol content

Release of active substances ranges from zero-order kinetics at high glycerol content to first-order kinetics at 40 phr

 
 phr: weight parts of glycerol per hundred weight parts of silicone
Zero order_graph_only one sample.png

Examples of technology key features

Storage stability is demonstrated for multiple reactive substances –
when loaded to different compartments in glycerol-silicone matrix
 
Multiple actives are released independently 

 
 phr: weight parts of glycerol per hundred weight parts of silicone
Independent release profiles_graph.png
Three Franz Cells.jpg

Release studies of selected active substances 

Screenshot 2024-04-25 at 12.39.05.png

Forms / way of the delivery

Intellectual property

Screenshot 2023-05-05 at 17.00.40.png

Stable mixtures of glycerol in silicon

Screenshot 2023-05-05 at 16.30.59.png

Controlled active substance release from adhesives

Screenshot 2023-05-05 at 17.01.02.png

New patent filed August 2023

Invention is covered by two broad patents either granted or in national/regional phase


New patent filed recently supporting the technology platform

Inventor:  Renowned pioneer within silicone elastomers 

Anne Ladegaard Skov, Dr. Techn. and professor at the Technical University of Denmark (DTU) is the main inventor of the Glysious technology

She heads the Danish Polymer Centre at DTU and leads several projects, including the Challenge Grant WeArAble (Novo Nordisk Foundation) and Spinout DK (Villum Foundation)

The inventor has received multiple awards, including Eliteforsk Prize (Danish Research Council), Grundfos Prize, Statoil Prize and the Elastyren Prize (Danish Academy of Technical Sciences)

WEB_4Y9A9239.jpg

Funding awarded for technology and product development

sdf.png
DTU logo.png
in.png

Enabling innovation in multiple industries

Publications

Green silicone

elastomer obtained

from a counterintuitively stable mixture of glycerol and PDMS

Screenshot 2024-04-23 at 18.13.05.png

Glycerol-silicone adhesives with excellent fluid handling and mechanical properties for advanced wound care applications

Glycerol-silicone adhesives with excellent fluid handling and mechanical properties for ad

Glycerol-silicone elastomers as active matrices with controllable release profiles

Screenshot 2024-04-23 at 19.18.51.png

Enzyme encapsulation in glycerol-silicone membranes for bioreactions and biosensors

bottom of page